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Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome. Pertovaara et al.
Clinical Immunology (2016) doi:10.1016/j.clim.2016.03.010 [View Abstract]
Inflammation, Cell Biology
Enhanced multiplexing in mass cytometry using osmium and ruthenium tetroxide species. Catena et al.
Cytometry Part A (2016) doi:10.1002/cyto.a.22848 [View Abstract]
Methods
Multi-parametric cytometry from a complex cellular sample: Improvements and limits of manual versus computational-based interactive analyses. Gondois-Rey et al.
Cytometry Part A (2016) doi:10.1002/cyto.a.22850 [View Abstract]
Informatics
In Vitro Culture of Human Hematopoietic Stem Cells in Serum Free Medium and Their Monitoring by Flow Cytometry. Cloutier et al.
Methods in Molecular Biology (2016) doi:10.1007/7651_2016_329 [View Abstract]
Methods
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma. Workel et al.
European Journal of Cancer (2016) doi:10.1016/j.ejca.2016.02.026 [View Abstract]
Cancer
Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation. Mingueneau et al.
Journal of Allergy and Clinical Immunology (2016) doi:10.1016/j.jaci.2016.01.024 [View Abstract]
Inflammation
Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments. Rahman et al.
Cytometry Part A (2016) doi:10.1002/cyto.a.22826 [View Abstract]
Methods
Deep Profiling Human T Cell Heterogeneity by Mass Cytometry. Cheng et al.
Advances in Immunology (2016) doi:10.1016/bs.ai.2016.02.002 [View Abstract]
Methods, Informatics
Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy. Greenplate et al.
Cancer Immunology Research (2016) doi:10.1158/2326-6066.CIR-15-0213 [View Abstract]
Cancer
High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy. Ferrell et al.
PLoS ONE (2016) doi:10.1371/journal.pone.0153207 [View Abstract]
Methods, Cancer, Informatics
ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Huth et al.
Journal of Translational Medicine (2016) doi:10.1186/s12967-016-0859-z [View Abstract]
Cell Biology
A global look into human T cell subsets before and after cryopreservation using multiparametric flow cytometry and two-dimensional visualization analysis. Lemieux et al.
Journal of Immunological Methods (2016) doi:10.1016/j.jim.2016.04.010 [View Abstract]
Methods
A multi-laboratory comparison of blood dendritic cell populations. Fromm et al.
Clinical and Translational Immunology (2016) doi:10.1038/cti.2016.5 [View Abstract]
Methods
Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets. van Unen et al.
Immunity (2016) doi:10.1016/j.immuni.2016.04.014 [View Abstract]
Inflammation
Application of Mass Cytometry (CyTOF) for Functional and Phenotypic Analysis of Natural Killer Cells. Kay et al.
Natural Killer Cells - Methods and Protocols (2016) doi:10.1007/978-1-4939-3684-7_2 [View Abstract]
Methods
Mass Cytometry: Single Cells, Many Features. Spitzer et al.
Cell (2016) doi:10.1016/j.cell.2016.04.019 [View Abstract]
Methods, Informatics
Systems immune monitoring in cancer therapy. Greenplate et al.
European Journal of Cancer (2016) doi:10.1016/j.ejca.2016.03.085 [View Abstract]
Cancer, Informatics
Characterization of Yellow Fever Virus Infection of Human and Non-human Primate Antigen Presenting Cells and Their Interaction with CD4+ T Cells. Cong et al.
Plos Neglected Tropical Diseases (2016) doi:10.1371/journal.pntd.0004709 [View Abstract]
Infectious diseases
The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells. Romano et al.
Oncotarget (2016) doi:10.18632/oncotarget.7895 [View Abstract]
Cancer
Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2. Hilbers et al.
Human Mutation (2016) doi:10.1002/humu.23019 [View Abstract]
Cancer
SCENERY: A Web-Based Application for Network Reconstruction and Visualization of Cytometry Data. Athineou et al.
10th International Conference on Practical Applications of Computational Biology & Bioinformatics, pp.203-211 (2016) doi:10.1007/978-3-319-40126-3_21 [View Abstract]
Informatics
Deep-phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment. Kordasti et al.
Blood (2016) doi:10.1182/blood-2016-03-703702 [View Abstract]
Autoimmunity
Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Pulko et al.
Nature Immunology (2016) doi:10.1038/ni.3483 [View Abstract]
Cell Biology
Visualization and cellular hierarchy inference of single-cell data using SPADE. Anchang et al.
Nature Protocols (2016) doi:10.1038/nprot.2016.066 [View Abstract]
Methods, Informatics
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. Lo and Silveira et al.
The Journal of Immunology (2016) doi:10.4049/​jimmunol.1600259 [View Abstract]
Cell Biology
Computational flow cytometry: helping to make sense of high-dimensional immunology data. Saeys et al.
Nature Reviews Immunology (2016) doi:10.1038/nri.2016.56 [View Abstract]
Methods, Informatics
Silver nanoparticles for the detection of cell surface antigens in mass cytometry. Schulz et al.
Cytometry Part A (2016) doi:10.1002/cyto.a.22904 [View Abstract]
Methods
An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. Davies et al.
Journal of Immunological Methods (2016) doi:10.1016/j.jim.2016.06.007 [View Abstract]
Methods
Activation of the reward system boosts innate and adaptive immunity. Ben-Shaanan et al.
Nature Medicine (2016) doi:10.1038/nm.4133 [View Abstract]
Neurology, Inflammation
Wild immunology assessed by multidimensional mass cytometry. Japp et al.
Cytometry Part A (2016) doi:10.1002/cyto.a.22906 [View Abstract]
Cell Biology
An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers. Chen et al.
Cancer Research (2016) doi:10.1158/0008-5472.CAN-15-2743 [View Abstract]
Cancer, Drug Discovery
Phosphoprotein Detection by High-Throughput Flow Cytometry. Landskron et al.
Phospho-Proteomics: Methods and Protocols, Methods in Molecular Biology (2016) doi:10.1007/978-1-4939-3049-4_19 [View Abstract]
Methods
A Multi-Institution Phase 1 Trial of Ruxolitinib in Patients with Chronic Myelomonocytic Leukemia (CMML). Padron et al.
Clinical Cancer Research (2016) doi:10.1158/1078-0432.CCR-15-2781 [View Abstract]
Cancer
TCRVγ9 γδ T Cell Response to IL-33: A CD4 T Cell–Dependent Mechanism. Duault et al.
The Journal of Immunology (2016) doi:10.4049/​jimmunol.1500260 [View Abstract]
Cell Biology
Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery. Schlickeiser et al.
Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II, Methods in Molecular Biology (2016) doi:10.1007/978-1-4939-3139-2_15 [View Abstract]
Methods, Informatics
JAK2V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction–transplantation model. Brooks et al.
Experimental Hematology (2016) doi:10.1016/j.exphem.2015.09.006 [View Abstract]
Cell Biology
New insights into the phenotype of human dendritic cell populations. Clark et al.
Nature Clinical & Translational Immunology (2016) doi:10.1038/cti.2015.40 [View Abstract]
Cell Biology
The Human Innate Immunity Handbook. Montgomery RR, Bucala R.
World Scientific (2016) doi:10.1142/9614 [View Abstract]
Methods, Cell Biology, Informatics
Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection. Wanke-Jellinek et al.
The Journal of Immunology (2016) doi:10.4049/​jimmunol.1500597 [View Abstract]
Cell Biology
High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry. Nair et al.
Mucosal Immunology (2016) doi:10.1038/mi.2015.36 [View Abstract]
Cell Biology
Learning cell states from high-dimensional single-cell data. Levine JH.
Columbia University Academic Commons (2016) doi:10.7916/D88052DM [View Abstract]
Cancer, Informatics
The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. Chong et al.
The Journal of Antibiotics (2016) doi:10.1038/ja.2016.22 [View Abstract]
Cancer
viSNE and Wanderlust, two algorithms for the visualization and analysis of high-dimensional single-cell data. Amir, El-ad David.
Columbia University Academic Commons (2014) doi:10.7916/D8SB43VK [View Abstract]
Informatics
Metal-Conjugated NeutrAvidin for MHC Multimer Assays Using Mass Cytometry. Ornatsky et al.
MBL International Scientific Posters (2016) [View Abstract]
Methods, Cell Biology
Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease. Kim et al.
Blood (2015) doi:10.1182/blood-2015-04-637587 [View Abstract]
Inflammation, Cell Biology
Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells. Chellappa et al.
Journal of Leukocyte Biology (2015) doi:10.1189/jlb.2HI0815-334R jlb.2HI0815-334R [View Abstract]
Inflammation, Cell Biology
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1). Uppal et al.
Clinical Cancer Research (2015) doi:10.1158/1078-0432.CCR-14-2093 [View Abstract]
Cell Biology
Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Divakar et al.
Nature Leukemia (2015) doi:10.1038/leu.2015.185 [View Abstract]
Cell Biology, Cancer, Drug Discovery
Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells. Linley et al.
Blood (2015) doi:10.1182/blood-2015-04-640805 [View Abstract]
Cell Biology, Cancer
Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth. Gaudillière et al.
Cytometry Part A (2015) doi:10.1002/cyto.a.22720 [View Abstract]
Cell Biology
The targeting of human and mouse B lymphocytes by dasatinib. Oksvold et al.
Experimental Hematology (2015) doi:10.1016/j.exphem.2015.01.008 [View Abstract]
Cell Biology, Cancer
STAT-5 is activated constitutively in T cells, B cells and monocytes from patients with primary Sjögren's syndrome. Pertovaara et al.
Clinical and Experimental Immunology (2015) doi:10.1111/cei.12614 [View Abstract]
Cell Biology
n Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment. Shah et al.
Neoplasia (2015) doi:10.1016/j.neo.2015.11.006 [View Abstract]
Cancer, Informatics
Anti-inflammatory effects of miR-21 in the macrophage response to peritonitis. Barnett et al.
Journal of Leukocyte Biology (2015) doi:10.1189/jlb.4A1014-489R [View Abstract]
Inflammation
Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia. Selimoglu-Buet et al.
Blood (2015) doi:10.1182/blood-2015-01-620781 [View Abstract]
Cancer
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Sagiv-Barfi et al.
PNAS (2015) doi:10.1073/pnas.1500712112 [View Abstract]
Cancer, Drug Discovery
Signaling impairments in maternal T cells engrafted in an infant with a novel IL-2 receptor g mutation. Khanolkar et al.
The Journal of Allergy and Clinical Immunology (2015) doi:10.1016/j.jaci.2015.02.012 [View Abstract]
Cell Biology
Revisiting Cardiac Cellular Composition. Pinto et al.
Circulation Research (2015) doi:10.1161/CIRCRESAHA.115.307778 [View Abstract]
Cell Biology, Cardiology
Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls. Tavenier et al.
BMC Immunology (2015) doi:10.1186/s12865-015-0136-6 [View Abstract]
Cell Biology
Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model. Hasan et al.
Oncotarget (2015) doi:10.18632/oncotarget.2842 [View Abstract]
Cancer
Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous. Mukherjee et al.
Nature Scientific Reports (2015) doi:10.1038/srep13886 [View Abstract]
Inflammation
Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis. Tang et al.
Experimental Hematology (2015) doi:10.1016/j.exphem.2015.04.007 [View Abstract]
Cancer
Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry. Nicholas et al.
Cytometry Part A (2015) doi:10.1002/cyto.a.22799 [View Abstract]
Methods, Informatics
LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients. Cazzaniga et al.
Oncotarget (2015) doi:10.18632/oncotarget.2807 [View Abstract]
Cell Biology
Multiparameter Phenotyping of Human PBMCs Using Mass Cytometry. Leipold et al.
Immunosenecence: Methods and Protocols, Methods in Molecular Biology (2015) doi:10.1007/978-1-4939-2963-4_7 [View Abstract]
Methods
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys. Smith et al.
Nature Scientific Reports (2015) doi:10.1038/srep17943 [View Abstract]
Cancer
In-depth characterization of CD24highCD38high transitional human B cells reveals different regulatory profiles. Simon et al.
Journal of Allergy and Clinical Immunology (2015) doi:10.1016/j.jaci.2015.09.014 [View Abstract]
Cell Biology
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis. Levine et al.
Cell (2015) doi:10.1016/j.cell.2015.05.047 [View Abstract]
Cancer, Informatics
Heterogeneity of in vitro–cultured CD34+ cells isolated from peripheral blood. Jobin et al.
Cytotherapy (2015) doi:10.1016/j.jcyt.2015.05.006 [View Abstract]
Informatics, Stem Cells
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms. Yajnanarayana SP et al.
British Journal of Haematology (2015) doi: 10.1111/bjh.13373 [View Abstract]
Cell Biology, Cancer, Drug Discovery
JAK inhibition impairs NK cell function in myeloproliferative neoplasms. Schonberg K et al.
Cancer Research (2015) (2015) doi: 10.1158/0008-5472.CAN-14-3198 [View Abstract]
Cell Biology, Cancer, Drug Discovery
Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. Kayser BD et al.
PLOS One (2015) (2015) doi: 10.1371/journal.pone.0121954 [View Abstract]
Hyperlipidemia, Cell Biology
Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression. Lutz C et al.
Clinical & Experimental Immunology (2015) doi: 10.1111/cei.12635 [View Abstract]
Cell Biology, Cancer, Drug Discovery
Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B. Grange et al.
Immunology (2015) doi: 10.1111/imm.12471 [View Abstract]
Cell Biology, Cancer
Reduced expression of peroxisome proliferator-activated receptor alpha in BAL and blood T cells of non-lšfgren's sarcoidosis patients. Hayja et al.
Journal of Inflammation (2015) doi: 10.1186/s12950-015-0071-6 [View Abstract]
Inflammation, Cell Biology
Meeting the challenges of measuring human immune regulation. Martino et al.
Journal of Immunological Methods (2015) doi:10.1016/j.jim.2015.04.016 [View Abstract]
Methods, Cell Biology, Informatics
Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data. Diggins et al.
Methods (2015) doi:10.1016/j.ymeth.2015.05.008 [View Abstract]
Methods, Informatics
A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011). Loh et al.
Pediatric Blood & Cancer (2015) doi:10.1002/pbc.25575 [View Abstract]
Cancer
ISAC's Gating-ML 2.0 data exchange standard for gating description. Spidlen et al.
Cytometry Part A (2015) doi:10.1002/cyto.a.22690 [View Abstract]
Informatics
Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy. Nair et al.
Arthritis Research & Therapy (2015) doi:10.1186/s13075-015-0644-z [View Abstract]
Methods, Informatics
Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model. McArthur et al.
Plos Pathogens (2015) doi:10.1371/journal.ppat.1004914 [View Abstract]
Infectious diseases, Cell Biology
NetworkPainter: dynamic intracellular pathway animation in Cytobank. Karr et al.
BMC Bioinformatics (2015) doi:10.1186/s12859-015-0602-4 [View Abstract]
Methods, Informatics
Mass Cytometry: An Evolution in ICP-MS Enabling Novel Insights in Single-Cell Biology. Virani et al.
Spectroscopy (2015) [View Abstract]
Methods
Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus . O'Gorman et al.
Journal of Allergy and Clinical Immunology (2015) doi:10.1016/j.jaci.2015.04.008 [View Abstract]
Methods, Inflammation, Informatics
Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease. Toapanata et al.
Plos Neglected Tropical Diseases (2015) doi:10.1371/journal.pntd.0003837 [View Abstract]
Infectious diseases, Cell Biology
Impact of recent innovations in the use of mass cytometry in support of drug development. Nassar et al.
Drug Discovery Today (2015) doi:10.1016/j.drudis.2015.06.001 [View Abstract]
Methods, Drug Discovery
Automatic single cell segmentation on highly multiplexed tissue images. Schuffler et al.
Cytometry Part A (2015) doi:10.1002/cyto.a.22702 [View Abstract]
Methods, Informatics
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. Polikowsky et al.
Journal of Immunology (2015) doi: 10.4049/​jimmunol.1500904 [View Abstract]
Cell Biology
An interactive reference framework for modeling a dynamic immune system. Spitzer et al.
Science (2015) doi:10.1126/science.1259425 [View Abstract]
Methods, Cell Biology, Informatics
A combination of high dose rate (10X FFF/2400?MU/min/10?MV X-rays) and total low dose (0.5?Gy) induces a higher rate of apoptosis in melanoma cells in vitro and superior preservation of normal melanocytes. Sreeja et al.
Melanoma Research (2015) doi: 10.1097/CMR.0000000000000174 [View Abstract]
Inflammation, Cell Biology
Algorithmic Tools for Mining High-Dimensional Cytometry Data. Chester et al.
Journal of Immunology (2015) doi: 10.4049/​jimmunol.1500633 [View Abstract]
Informatics
Single cell mass cytometry reveals remodeling of human T cell phenotypes by varicella zoster virus. Sen et al.
Methods (2015) doi:10.1016/j.ymeth.2015.07.008 [View Abstract]
Methods, Cell Biology
Big data comes in tiny packages: single-cell driven science and health. Sachs et al.
XRDS: Crossroads, The ACM Magazine for Students - Computational Biology (2015) doi:10.1145/2788516 [View Abstract]
Informatics
FlowGate: towards extensible and scalable web-based flow cytometry data analysis. Yu et al.
XSEDE '15 Proceedings of the 2015 XSEDE Conference: Scientific Advancements Enabled by Enhanced Cyberinfrastructure (2015) doi:10.1145/2792745.2792750 [View Abstract]
Informatics
Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry. Mason et al.
Journal of Immunology (2015) doi:10.4049/​jimmunol.1500703 [View Abstract]
Cell Biology, Informatics
Direct Isolation of Exosomes from Cell Culture: Simplifying Methods for Exosome Enrichment and Analysis. Pedersen et al.
Translational Biomedicine (2015) [View Abstract]
Methods
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. Duque-Afonso et al.
Journal of Clinical Investigation (2015) doi:10.1172/JCI81158 [View Abstract]
Cancer
Platinum-conjugated antibodies for application in mass cytometry. Mei et al.
Cytometry Part A (2015) doi:10.1002/cyto.a.22778 [View Abstract]
Methods
Treatment regimen, surgical outcome and T cell differentiation influence prognostic benefit of tumor-infiltrating lymphocytes in high grade serous ovarian cancer. Wouters et al.
Clinical Cancer Research (2015) doi:10.1158/1078-0432.CCR-15-1617 [View Abstract]
Cancer
Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human IL21 receptor-blocking therapeutic antibody. Xue L et al.
Clinical & Experimental Immunology (2015) doi:10.1111/cei.12711 [View Abstract]
Cell Biology, Drug Discovery
Cyclic dinucleotides modulate human T-cell response through monocyte cell death. Tosolini et al.
European Journal of Immunology (2015) doi:10.1002/eji.201545697 [View Abstract]
Cell Biology
Characterization of lung infection–induced TCRγδ T cell phenotypes by CyTOF mass cytometry. Wanke-Jellinek et al.
Journal of Leukocyte Biology (2015) doi:10.1189/jlb.4A0315-115RR [View Abstract]
Inflammation, Cell Biology
Cytometry‐based single‐cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF‐α‐induced apoptosis in vivo. Simmons et al.
Molecular Systems Biology (2015) doi: 10.15252/msb.2015628 [View Abstract]
Methods, Cancer
Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. Cols et al.
Journal of Allergy and Clinical Immunology (2015) doi:10.1016/j.jaci.2015.09.013 [View Abstract]
Inflammation, Cell Biology
Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry. Leelatian et al.
Methods in Molecular Biology (2015) doi:10.1007/978-1-4939-2987-0_8 [View Abstract]
Methods, Informatics
Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery. Schlickeiser et al.
Methods in Molecular Biology (2015) doi:10.1007/978-1-4939-3139-2_15 [View Abstract]
Methods, Informatics
Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry. Leong et al.
Methods in Molecular Biology (2015) doi:10.1007/978-1-4939-2987-0_9 [View Abstract]
Methods, Informatics
RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Ksionda et al.
Nature Oncogene (2015) doi:10.1038/onc.2015.431 [View Abstract]
Cell Biology, Cancer
Flow Cytometry Bioinformatics. O'Neill et al.
PLOS Computational Biology (2015) doi:10.1371/journal.pcbi.1003365 [View Abstract]
Methods, Informatics
The end of gating? An introduction to automated analysis of high dimensional cytometry data. Mair et al.
European Journal of Immunology (2015) doi:10.1002/eji.201545774 [View Abstract]
Methods, Informatics
Computational prediction of manually gated rare cells in flow cytometry data. Qiu P.
Cytometry Part A (2015) doi: 10.1002/cyto.a.22654 [ View Abstract]
Informatics, Methods
High Expression of CD26 Accurately Identifies Human Bacterial-Reactive MR1-restricted MAIT cells. Sharma PK et al.
Immunology (2015) doi: 10.1111/imm.12461 [View Abstract]
Cell Biology, Infectious Diseases
Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging. Levenson RM, Borowsky AD, Angelo M.
Laboratory Investigation (2015) doi: 10.1038/labinvest.2015.2 [Full Article]
Methods
STAT5 is constitutively activated in T cells, B cells and monocytes from patients with primary Sjögreńs syndrome. Pertovaara M et al.
Clin Exp Immunol (2015) doi: 10.1111/cei.12614 [View Abstract]
Cell Biology
A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus. Stolp ZD et al.
J Biomol Screen (2015) doi:10.1177/1087057115571247 [View Online]
Infectious Diseases, Methods
A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry. Zunder E et al. Cell Stem Cell (2015) doi: 10.1016/j.stem.2015.01.015 [View Abstract] Stem Cells
A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells. Levy O et al. Cell Reports (2015) doi: 10.1016/j.celrep.2015.01.057 [View Online] Methods, Drug Discovery
Phenotype and function of nasal dendritic cells. Lee H et al. Mucosal Immunology (2015) doi: 10.1038/mi.2014.135 [View Abstract] Cell Biology
Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in syngeneic mouse lymphoma model. Sagiv-Barfi I et al. Blood (2015) doi: 10.1182/blood-2014-08-593137 [View Abstract] Cancer
Chikungunya viral arthritis in the United States: A mimic of seronegative rheumatoid arthritis. Miner JJ, Aw-Yeang H et al. Arthritis & Rheumatology (2015) doi: 10.1002/art.39027. [View Abstract] Infectious Diseases
Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Zunder E and Finck R et al. Nature Protocols (2015) 10, 316–333. doi:10.1038/nprot.2015.020 [View Online] Methods, Informatics
Bioinformatics Approaches for Automated Cell Phenotyping. Conroy R and Pai V. Computational Optical Biomedical Spectroscopy and Imaging (2015) [Book Chapter] Methods, Informatics
Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo. Das R et al. J Immunol (2014) doi: 10.4049/​jimmunol.1401686 [Abstract] Cancer
G-Protein-coupled Bile Acid Receptor 1 (GPBAR1, TGR5) agonists reduce the production of pro-inflammatory cytokines and stabilize the alternative macrophage phenotype. Hoegenauer K et al. J. Med. Chem. (2014) doi: 10.1021/jm501052c [Abstract] Inflammation
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Landskron J et al. Cancer Immunology, Immunotherapy (2014) doi: 10.1007/s00262-014-1636-6 [Abstract] Cancer
The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels. Isomäki P et al. Rheumatology (2014) doi: 10.1093/rheumatology/keu430 [Abstract] Rheumatoid Arthritis
Beyond the age of cellular discovery. Irish JM. Nature Immunology (2014) 15, 1095–1097. doi:10.1038/ni.3034 [View Online] Cell Biology
CyTOF supports efficient detection of immune cell subsets from small samples. Yao Y et al. Journal of Immunological Methods (2014) doi: 10.1016/j.jim.2014.10.010. [View Abstract] Methods
HemI: A Toolkit for Illustrating Heatmaps. Deng W, Wang Y, Liu Z, Cheng H, Xue Y. PLoS ONE (2014) 9(11): e111988. doi:10.1371/journal.pone.0111988 [View Online] Methods, Informatics
Mass Cytometry: A Highly Multiplexed Single Cell Technology for Advancing Drug Development. Atkuri KR, Stevens JC, and Neubert H. Drug Metabolism and Disposition (2014) doi: 10.1124/dmd.114.060798 [View Online] Methods, Drug Discovery
Regulation and Heterogeneity of Pancreatic Natural Killer Cells During Type 1 Diabetes. Sitrin JR. (2014). Doctoral Dissertation: The Division of Medical Sciences, Harvard University, Graduate School of Arts and Sciences. [View Online] Diabetes
A variety of pesticides trigger in vitro α-synuclein accumulation, a key event in Parkinson’s disease. Chorfa, A et al. Archives of Toxicology (2014) doi: 10.1007/s00204-014-1388-2 [View Abstract] Neurology
Rapid determination of IL-6 specific activity by flow cytometry. Simard C et al. Journal of Immunological Methods (2014) doi: 10.1016/j.jim.2014.09.005. [View Abstract] Methods, Cell Biology
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Trends in single-cell analysis by use of ICP-MS. Mueller L et al. Analytical and Bioanalytical Chemistry (2014) doi: 10.1007/s00216-014-8143-7. [View Abstract] Methods
Clinical Recovery from Surgery Correlates with Single-Cell Immune Signatures. Gaudilliere B and Fragiadakis G et al. Sci. Transl. Med. (2014) doi: 10.1126/scitranslmed.3009701. [Journal] Surgery
Systems Biology and Immune Aging. O’Connor JE et al. Immunology Letters (2014) doi: 10.1016/j.imlet.2014.09.008. [Abstract] Surgery, Informatics
Mass Cytometry Analysis of Human T Cell Phenotype and Function. Newell EW and Li Yun L. T-Helper Cells — Methods in Molecular Biology (2014) doi: 10.1007/978-1-4939-1212-4_7. [View Online] Methods
OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis. Finak G et al. PLoS Comput Biol. (2014) 10(8): e1003806. [View Online] Methods, Informatics
High-Dimensional Single-Cell Cancer Biology. Irish JM and Doxie DB. High-Dimensional Single Cell Analysis: Mass Cytometry, Multi-Parametric Flow Cytometry and Bioinformatic Techniques (2014) doi: 10.1007/82_2014_367. [Book Chapter] Methods, Cell Biology
Unraveling cell populations in tumors by single-cell mass cytometry. Di Palma S. and Bodenmiller B. Current Opinion in Biotechnology (2014) doi: 10.1016/j.copbio.2014.07.004. [View Abstract] Methods, Informatics
Characterization of signaling networks in ovarian cancer cells. Flage-Larsen L. (2014) Master Thesis: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences. [View Online] Cancer
Toward effective sharing of high-dimensional immunology data. Snijder B et al. Nature Biotechnology (2014) 32: 755–759. doi:10.1038/nbt.2974. [Journal] Methods, Informatics
Features of free software packages in flow cytometry: a comparison between four non-commercial software sources. Sahraneshin SF et al. Cytotechnology (2014) vol. 66, no4, pp. 555-559. [View Abstract] Methods
Multiplexed Phosphospecific Flow Cytometry Enables Large-scale Signaling Profiling and Drug Screening in Blood Platelets. Spurgeon BEJ et al. Journal of Thrombosis and Haemostasis (2014) doi:10.1111/jth.12670. [View Abstract] Methods, Drug Discovery
Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVγ9+ γδ T lymphocytes. Decaup E et al. Science Direct (2014) doi:10.1016/j.imlet.2014.05.011. [Journal] Cancer
DNA Methylation Is Altered In B And Nk Lymphocytes In Obese And Type 2 Diabetic Human. Simar D et al. Science Direct (2014) doi:10.1016/j.metabol.2014.05.014. [Journal] Diabetes
Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia. Perova T et al. Sci Transl Med (2014) 6:236ra62 doi:10.1126/scitranslmed.3008661. [View Abstract] Cancer
Targeting CD137 enhances the efficacy of cetuximab. Kohrt HE et al. J Clin Invest (2014) doi:10.1172/JCI73014. [View Online] Cancer
Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development. Bendall SC et al. Cell (2014) doi:10.1016/j.cell.2014.04.005. [View Online] Methods, Cell Biology, Informatics
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Bharadwaj U et al. Oncogene 0 (2014) doi:10.1038/onc.2014.72. [View Online] Cancer, Drug Discovery
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signaling responses. Skånland SS et al. Biochemical Journal (2014) doi:10.1042/BJ20140040. [Journal] Cancer
Plasma and lymphocyte Hsp72 responses to exercise in athletes with prior exertional heat illness. Ruell RA et al. Springer Link (2014) doi:10.1007/s00726-014-1721-3. [View Online] Inflammation, Cell Biology
Elevated plasma PCSK9 is equally detrimental for non-familial hypercholesterolemic (non-FH) and heterozygous FH patients, irrespective of their LDL receptor defects ONLINE FIRST. Gilles L et al. J Am Coll Cardiol (2014) doi:10.1016/j.jacc.2014.02.538. [Journal] Hyperlipidemia
Cytobank: Providing and Analytics Platform for Community Cytometry Data Analysis and Collaboration. Chen TJ and Kotecha N. Curr Top Microbiol Immunol (2014) 377:127-57. doi: 10.1007/82_2014_364. [PubMed] Methods, Informatics
High multiplexed imaging of tumor tissues with subcellular resolutions by mass cytometry. Giesen C et al. Nature Methods (2014) doi:10.1038/nmeth.2869. [View Online] Methods
Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralization Antibodies in Multiple Sclerosis Patients with Interferon-Beta. Gavasso S et al. PLoS ONE (2014) doi:10.1371/journal.pone.0088632. [Journal] Neurology
Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution. Orr JS et al. Diabetes (2014) 63(2):421-32. doi: 10.2337/db13-0213. [PubMed] Diabetes
Killer B Cells: Regulation of the Growth and Function of Fas Ligand-Expressing B Lymphocytes. Klinker MW (2013). Doctoral Dissertation: Department of Philosophy (Immunology), University of Michigan. [View Online] Cell Biology, Cancer
Unifying immunology with informatics and multiscale biology. Kidd BA et al. Nature Immunology (2014) 15:118-127. doi:10.1038/ni.2787. [View Online] Methods, Informatics
A Simple FCM Method to Avoid Misinterpretation in Saccharomyces cerevisiae Cell Cycle Assessment between G0 and Sub-G1. Delobel P, Tesnière C. PLoS ONE (2014) 9(1): e84645. doi:10.1371/journal.pone.0084645. [Journal] Methods
flowUtils: Gating-ML Support In Flow Cytometry. Spidlen J. (2013) [View Online] Methods, Informatics
2D Visualization of High-Dimensional Molecular Data from Single-Cell Mass Cytometry. Dong Y, Wan D. (2013) [View Online]
Flow Cytometry Bioinformatics. O’Neill K, Aghaeepour N, Špidlen J, Brinkman R. PLoS Comput Biol (2013) 9(12): e1003365. doi:10.1371/journal.pcbi.1003365. [Journal] Methods, Informatics
Spectral Flow Cytometry Makes Debut. Liszewski K. (2013) Genetic Engineering & Biotechnology News December 1, 2013, 33(21): 1, 20-21. doi:10.1089/gen.33.21.08. [Journal] Methods
Flow Cytometry and Cell Sorting: A Practical Guide. Haron J. Labome (2013) doi: http://dx.doi.org/10.13070/mm.en.3.165 [Journal] Methods
Phase II Study Of The Oral MEK Inhibitor Selumetinib In Advanced Acute Myeloid Leukemia (AML): A UniversityOf Chicago Phase II Consortium Trial. Jain N et al. Clin Cancer Res (2013) 20(2):490-8. doi: 10.1158/1078-0432.CCR-13-1311. [PubMed] Cancer, Drug Discovery
Feasibility study: phospho-specific flow cytometry enabling rapid functional analysis of bone marrow samples from patients with multiple myeloma. Simard C et al. Cytometry B Clin Cytom (2013) Epub ahead of print. [PubMed] Cancer
The rotavirus NSP1 protein inhibits IFN-mediated STAT1 activation. Sen A et al. J Virol (2013) 88(1):41-53. doi: 10.1128/JVI.01501-13. [PubMed] Infectious Diseases
ErbB3 downregulation enhances luminal breast tumor response to antiestrogens. Morrison MM et al. J Clin Invest (2013) 123(10):4329-43. doi: 10.1172/JCI66764. [PubMed] Cancer
Single-cell mass cytometry for analysis of immune system functional states. Bjornson ZB et al. Curr Opin Immunol (2013) 25(4):484-94. [PubMed] Methods, Cell Biology
Imbalanced Frequencies of Th17 and Treg Cells in Acute Coronary Syndromes Are Mediated by IL-6-STAT3 Signaling. Ma Y et al. PLoS One (2013) 8(8):e72804. [PubMed] Cell Biology, Cardiology
Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model. Decaup E et al. Blood Cancer J (2013) 3:e131. [PubMed] Cancer
Interleukin-5 Supports the Expansion of Fas Ligand-Expressing Killer B Cells that Induce Antigen-Specific Apoptosis of CD4(+) T Cells and Secrete Interleukin-10. Klinker MW et al. PLoS One (2013) 8(8):e70131. [PubMed] Cancer
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis. Størvold GL et al. J Proteomics (2013) 91:344-57. doi: 10.1016/j.jprot.2013.07.019. [PubMed] Cell Biology
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. Bredholt T et al. BMC Pharmacol Toxicol (2013) 14(1):35. [PubMed] Cancer
Evolution of flow cytometry as a drug screening platform. Jepras R and Ludbrook S. Drug Discovery World (2013) [Journal] Methods, Drug Discovery
Immune monitoring in cancer vaccine clinical trials: critical issues of functional flow cytometry-based assays. Macchia I et al. Biomed Research Intl (2013) vol. 2013, Article ID 726239, 11 pages, 2013. doi:10.1155/2013/726239. [Journal] Cancer
GenePattern flow cytometry suite. Spidlen J et al. Source Code Biol Med (2013) 8(1):14. [PubMed] Methods, Informatics
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Amir el-AD et al. Nat Biotechnol (2013) 31(6):545-52. [PubMed] Methods, Informatics
Profound impairment of adaptive immune responses by alkylating chemotherapy. Litterman AJ et al. J Immunol (2013) 190(12):6259-68. [PubMed] Informatics
Detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Gaipa G et al. Cytometry B Clin Cytom (2013) 84(6):359-69. doi: 10.1002/cyto.b.21101. [PubMed] Cancer
Saccharomyces cerevisiae deletion strains with complex DNA content profiles. Hoose SA et al. FEMS Microbiol Lett (2013) 345(1):72-6. doi: 10.1111/1574-6968.12186. [PubMed] Infectious Diseases
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. Marabelle A et al. J Clin Invest (2013) 123(6):2447-63. [PubMed] Cancer
Isolation of adipose tissue immune cells. Orr JS et al. J Vis Exp (2013) (75) [PubMed] Methods
The transcriptional landscape of αβ T cell differentiation. Mingueneau M, et al. Nat Immunol (2013) 14(6):619-32 [PubMed] Cell Biology
TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb. Patel AS et al. EMBO Mol Med (2013) 5(6):858-69 [PubMed] Vascular Diseases
GM-CSF dependent STAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia. Padron E, et al. Blood (2013) 121(25):5068-77. doi: 10.1182/blood-2012-10-460170. [PubMed] Cancer
Evaluation of interferon-beta neutralizing antibodies in individual patients with multiple sclerosis based on phospho-specific flow cytometry. Gavasso S. (2013) Doctoral Dissertation: Neuro-immunology Laboratory and the Multiple Sclerosis Competence Center, Department of Neurology, University of Bergen [View Online] Neurology
Normalization of mass cytometry data with bead standards. Finck F, et al. Cytometry Part A (2013) 83A(5):483-94 [PubMed] Methods, Informatics
An introduction to mass cytometry: fundamentals and applications. Tanner SD, et al. Cancer Immunol Immunother (2013) 62(5):955-65 [PubMed] Methods
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Vang T, et al. Hum Immunol (2013) 74(5):574-85 [PubMed] Cancer
EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry. Cornez I, et al. J Neurooncol (2013) 112(1):49-57 [PubMed] Cancer
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Myklebust JH et al. Blood (2013) 121(8):1367-76 [PubMed] Cancer
Evaluation and purchase of an analytical flow cytometer: some of the numerous factors to consider. Zucker RM and Fisher NC. Curr Protoc Cytom (2013) Chapter 1:Unit1.28. doi: 10.1002/0471142956.cy0128s63 [PubMed] Methods
Use of Phospho-flow Cytometry to Define Influence of High-Risk Genetic Abnormalities on Cytokine-Responsiveness in Human B-cell Leukemia. Kraguljac AP. Dissertation: Univ of Toronto (2012) Graduate Department of Medical Biophysics, Faculty of Medicine. [Google Scholar] Methods, Cancer
Isolation and characterization of cancer stem cells in vitro. Geydye C and Ailles L. Methods Mol Biol (2013) 946:181-204. [PubMed] Inflammation, Cancer
Nitroreductase, a near infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. McCormack E et al. Cancer Res (2012) 73(4):1276-86 [PubMed] Inflammation, Cancer
Interleukin-33 Drives a Proinflammatory Endothelial Activation That Selectively Targets Nonquiescent Cells. Pollheimer J et al. Arterioscler Thromb Vasc Biol (2012) 33(2):e47-55 [PubMed] Vascular Diseases
Aberrant kinase activation as a therapy target: Chronic myeloid leukemia as a model disease. Hernesniemi S. (2012). Doctoral Dissertation: Hematology Research Unit, Biomedicum, University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine. [View Online] Cancer
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. Blix ES et al. BMC Cancer (2012) 12:478 [PubMed] Cancer
RchyOptimyx: Cellular hierarchy optimization for flow cytometry. Aghaeepour N et al. Cytometry A (2012) 81A(12):1022-30 [PubMed] Methods, Informatics
The various faces of autoimmune endocrinopathies: Non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis. Melcescu E et al. Exp Mol Pathol (2012) 93(3):434-40 [PubMed] Inflammation
Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. Husel K et al. PLoS ONE (2012) e46117. doi:10.1371/journal.pone.0046117 [Journal] Cancer
Self-antigen recognition by follicular lymphoma B cell receptors. Sachen KL et al. Blood (2012) 120(20):4182-90 [PubMed] Cancer
Big data in computational biology. Chan C. XRDS: Crossroads (2012) 19(1):64-68. [Journal] Methods, Informatics
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia (ALL). Maude SL et al. Blood (2012) 120(17):3510-18 [PubMed] Methods, Cancer
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Bodenmiller B et al. Nat Biotechnol (2012) 30:858-67 [PubMed] Methods, Informatics, Drug Discovery
Preparing a Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) Compliant Manuscript Using the International Society (ISAC) FCS File Repository (FlowRepository.org). Spidlen J, Breuer K, and Brinkman R. Curr Protoc Cytom (2012) Chapter 10:Unit10.18. [PubMed] Methods, Informatics
CytoSPADE: High-Performance Analysis and Visualization of High-Dimension Cytometry Data. Linderman MD, et al. Bioinformatics (2012) 28(18):2400-01 [PubMed] Methods, Informatics
FlowRepository: A resource of annotated flow cytometry datasets associated with peer-reviewed publications. Spidlen J, et al. Cytometry A (2012) doi: 10.1002/cyto.a.22106 [Journal] Methods, Informatics
Computational analysis of high-throughput flow cytometry data. Robinson JP et al. Expert Opin Drug Discov (2012) 7(8):679-93 [PubMed] Methods, Informatics
Single-cell mass cytometry adapted to measurements of the cell cycle. Behbehani GK et al. Cytometry A (2012) 81A(7):552-66 [PubMed] Methods
Modulation of proximal signaling in normal and transformed B cells by transmembrane adaptor Cbp/PAG. Solheim SA et al. Exp Cell Res (2012) 318(14):1611-19 [PubMed] Cell Biology
A platinum-based covalent viability reagent for single-cell mass cytometry. Fienberg HG et al. Cytometry A (2012) 81A(6):467-75 [PubMed] Methods
Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine. Hoose SA et al. PLoS ONE (2012) 7(5): e36503. [Journal] Cell Biology, Drug Discovery
A Computational Framework to Emulate the Human Perspective in Flow Cytometric Data analysis. Ray S and Pyne S. PLoS ONE (2012) 7(5): e35693. [Journal] Methods, Informatics
Encapsulation of angiogenic monocytes using bio-spraying technology. Patel AS et al. Integr Biol (2012) 6(4):628-32 [Journal] Methods
Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells. Huc L et al. Toxicol in Vitro (2012) 26(5):709-17 [Journal] Cell Biology
A deep profiler’s guide to cytometry. Bendall S et al. Trends Immunol (2012) 33(7):323-32 [Journal] Methods
Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects. Simar D et al. Cell Stress Chaperones (2012) 17(5):615-21 [PubMed] Diabetes
The Stanford Data Miner: a novel approach for integrating and exploring heterogeneous immunological data. Siebert J et al. J Transl Med (2012) 10(1):62 [PubMed] Methods, Informatics
A Systematic Analysis of Cell Cycle Regulators in Yeast Reveals That Most Factors Act Independently of Cell Size to Control Initiation of Division. Hoose SA et al. PLoS Genet (2012) 8(3):e1002590. [PubMed] Cell Biology
eIF2α Kinases Regulate Development through the BzpR Transcription Factor in Dictyosteliumdiscoideum. Singleton CK et al. PLoS One (2012) 7(3):e32500. [PubMed] Cell Biology
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy inxenotransplant models of breast cancer. Kohrt HE et al. J Clin Invest (2012) 122(3):1066-75. [PubMed] Cancer
Analyzing genomic data: understanding the genome. Fernández-Suárez XM. WIREs Data Mining Knowl Discov (2012) 2(2):116-137 [Journal] Informatics
Trogocytosis is a Gateway to Characterize Functional Diversity in Melanoma-Specific CD8+ T Cell Clones. Uzana R et al. J Immunol (2011) 188(2):632-4 [PubMed] Cancer
In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase I/II study. Kim YH et al. Blood (2011) 119(2):355-63 [PubMed] Cancer
Bone morphogenetic proteins inhibit CD40L/IL‐21‐induced Ig production in human Bcells: Differential effects of BMP‐6 and BMP‐7. Huse K et al. Eur J Immunol (2011) 41(11):3135-45 [PubMed] Cancer
T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells. Kalland ME et al. J Immunol (2011) 187(10):5233-45 [PubMed] Cancer
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol (2011) 29(10):886-91 [PubMed] Methods, Informatics
A regression model approach to enable cell morphology correction in high-throughput flow cytometry. Knijnenburg TA et al. Mol Syst Biol (2011) 7:531 [PubMed] Methods, Informatics
CpG and Non-CpG Oligodeoxynucleotides Directly Costimulate Mouse and Human CD4+ T Cells through a TLR9-and MyD88-Independent Mechanism. Landrigan A et al. J Immunol (2011) 187(6):3033-43 [PubMed] Cell Biology
Donor immunization with WT1 peptide augments anti-leukemic activity after MHC-matched bone marrow transplantation. Kohrt HE, et al. Blood (2011) 118(19):5319-29 [PubMed] Cancer
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons. Thomas C et al. Cell (2011) 146(4):621-32 [PubMed] Cell Biology
Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantification. Jefferson A et al. Atherosclerosis (2011) 219(2):579-87 [PubMed] Vascular Diseases, Methods
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Alizadeh AA et al. Blood (2011) 118(5):1350-8 [PubMed] Cancer
Leukemia inhibitory factor downregulates human papillomavirus-16 oncogene expression and inhibits the proliferation of cervical carcinoma cells. Bay JM et al. Infect Dis Obstet Gynecol (2011) 2011:463081. [PubMed] Cancer
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum. Bendall SC et al. Science (2011) 332(6030):687-96 [PubMed] Methods, Cell Biology, Drug Discovery
Flow cytometry data standards. Spidlen J et al. BMC Res Notes (2011) 4:50 [PubMed] Informatics
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CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Kohrt HE et al. Blood (2011) 117(8):2423-32 [PubMed] Cancer
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. J Skavland, et al. Blood Cancer Journal (2011) 1, e4 [Journal] Cancer
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Yuan TL et al. Curr Biol (2011) 21(3):173-83 [PubMed] Cell Biology
Fluorescent Cell Barcoding for Multiplex Flow Cytometry. Krutzik PO et al. Curr Protoc Cytom (2011) Chapter 6:Unit 6.31 [PubMed] Methods
Oxidative Stress Induces Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus and Death of Primary Effusion Lymphoma Cells. Li X et al. Journal of Virology (2011) 85(2):715-724 [PubMed] Cancer
Poor cytokine-induced phosphorylation in chronic myeloid leukemia patients at diagnosis is effectively reversed by tyrosine kinase inhibitor therapy. Jalkanen SE et al. Exp Hematol (2011) 39(1):102-113.e1 [PubMed] Cancer
Phospho Flow Cytometry: Single‐Cell Signaling Networks in Next‐Generation Drug Discovery and Patient Stratification. Krutzik PO et al. A chapter in “Flow Cytometry in Drug Discovery and Development” by Litwin V and Marder P (2011) pp. 303-334 [Google Books] Methods, Drug Discovery
A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors. Goldstein MJ et al. Blood (2011) 117(1):118-27 [PubMed] Cancer
Phospho Flow Cytometry Methods for the Analysis of Kinase Signaling in Cell Lines and Primary Human Blood Samples. Krutzik PO et al. Methods in Molecular Biology (2011) 699:179-202 [PubMed] Methods
The Role of Phosphoinositide 3-Kinase in Breast Cancer. Yuan T. DTIC Online (2010) Access number: ADA541781 Cancer
High-resolution mapping of prostaglandin E2–dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells. Oberprieler NG et al. Blood (2010) vol. 116(13):2253-2265 [PubMed] Cell Biology, Cancer
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Oh ST et al. Blood (2010) 116(6):988-92 [PubMed] Cancer
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Irish JM et al. Proc Natl Acad Sci U S A (2010) 107(29):12747-54 [PubMed] Cancer
Web-Based Analysis and Publication of Flow Cytometry Experiments. Kotecha N, Krutzik PO, and Irish JM. Curr Protoc Cytom (2010) Chapter 10:Unit10.17 [PubMed] Methods, Informatics
Access to the Spleen Microenvironment through Lymph Shows Local Cytokine Production, Increased Cell Flux, and Altered Signaling of Immune Cells during Lipopolysaccharide-Induced Acute Inflammation. Semaeva E et al. J Immunol (2010) 184(8):4547-56 [PubMed] Methods
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Soond DR et al. Blood (2010) 115(11):2203-13 [PubMed] Cell Biology, Cancer
High-Content Analysis – CHI’s Seventh Annual Conference – Flow Cytometry in Drug Discovery and Development. Robinson JP. IDrugs (2010) 13:153-155 [PubMed] Methods, Cancer, Drug Discovery
CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Luo RF et al. Human Pathology (2010) 41(2):271-280 [PubMed] Cancer
Generation of CD8+ T cell–mediated immunity against idiotype-negative lymphoma escapees. Varghese B et al. Blood (2009) 114(20):4477-4485 [PubMed] Cancer
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Houot R et al. Blood (2009) 114(16):3431-3438 [PubMed] Cancer
T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Houot R and Levy R. Blood (2009) 113(15):3546-3552 [PubMed] Cancer
WebFlow: a software package for high-throughput analysis of flow cytometry data. Hammer MM et al. Assay Drug Dev Technol (2009) 7(1):44-55 [PubMed] Methods, Informatics
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Kotecha N et al. Cancer Cell (2008) 14(4):335-43 [PubMed] Cancer, Informatics